Myeloid‐derived suppressor cells: Bridging the gap between inflammation and pancreatic adenocarcinoma

نویسندگان

چکیده

Pancreatic cancer has been identified as one of the deadliest malignancies because it remains asymptomatic and usually presents in advanced stage. Tumour immune evasion is a well-known mechanism tumorigenesis various forms human malignancies. Chronic inflammation via complex networking inflammatory cytokines local tissue microenvironment dysregulates system support tumour development. Pro-inflammatory mediators present increase burden by causing suppression through generation myeloid-derived suppressor cells (MDSCs) T regulatory cells. These cells, along-with myofibroblasts, create highly immunosuppressive resistant are thus considered culprits for failure anti-cancer chemotherapies pancreatic adenocarcinoma patients. Targeting these MDSCs using combinatorial approaches might have potential abrogating resistance suppressive nature microenvironment. Therefore, there more curiosity studying crosstalk with other during pathological conditions underlying mechanisms immunosuppression current scenario. In this article, possible role inflammation-mediated progression discussed.

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ژورنال

عنوان ژورنال: Scandinavian Journal of Immunology

سال: 2021

ISSN: ['0300-9475', '1365-3083']

DOI: https://doi.org/10.1111/sji.13021